Microstructures, mechanical properties and cytotoxicity of low cost beta Ti-Mn alloys for biomedical applications (2024)

Santos, P. F., Niinomi, M., Cho, K., Nakai, M., Liu, H., Ohtsu, N., Hirano, M., Ikeda, M. (2015). Microstructures, mechanical properties and cytotoxicity of low cost beta Ti-Mn alloys for biomedical applications. Acta Biomaterialia, 26, 366-376. https://doi.org/10.1016/j.actbio.2015.08.015

Santos, Pedro Fernandes ; Niinomi, Mitsuo ; Cho, Ken et al. / Microstructures, mechanical properties and cytotoxicity of low cost beta Ti-Mn alloys for biomedical applications. In: Acta Biomaterialia. 2015 ; Vol. 26. pp. 366-376.

@article{b5b415e6e7ff416db55b4ec8d9a6d316,

title = "Microstructures, mechanical properties and cytotoxicity of low cost beta Ti-Mn alloys for biomedical applications",

abstract = "The microstructures, mechanical properties and biocompatibility of low cost β-type Ti-(6-18)Mn alloys were investigated after solution treatment. Ti-9Mn exhibits the best combination of tensile strength and elongation among the fabricated alloys, and its performance is comparable to or superior to those of Ti-6Al-4V ELI (Ti-64 ELI) in terms of every parameter evaluated. A hardness of 338 HV, a Young's modulus of 94 GPa, a 0.2% proof stress of 1023 MPa, an ultimate tensile strength of 1048 MPa and elongation of 19% were obtained for Ti-9Mn. Furthermore, the cell viability and metallic ion release ratios are comparable to those of commercially pure titanium, making this alloy promising for biomedical applications. The Young's modulus is also lower than that of Ti-64 ELI (110 GPa), which can possibly reduce the stress shielding effect in implanted patients. Statement of significance This study evaluates mechanical and biological performance of low cost solution treated β-type Ti-(6, 9, 13 and 18 mass%)Mn alloys. It includes alloys containing a Mn content range higher than most previously published works (which is around or lower than 8 mass%). Furthermore, the effects of the ω phase and the β phase stability of the alloys over some mechanical properties and microstructures are discussed. Ion release behavior under simulated body fluids and cell viability are also evaluated. For the case of the Ti-9Mn, a mechanical and biological performance that is comparable to or superior than that of the widely used Ti-6Al-4V ELI and commercially pure Ti was observed.",

keywords = "Biocompatibility, Low cost Ti alloy, Mechanical properties, Ti-Mn alloys, β phase",

author = "Santos, {Pedro Fernandes} and Mitsuo Niinomi and Ken Cho and Masaaki Nakai and Huihong Liu and Naofumi Ohtsu and Mitsuhiro Hirano and Masahiko Ikeda and Takayuki Narushima",

note = "Publisher Copyright: {\textcopyright} 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.",

year = "2015",

month = oct,

day = "15",

doi = "10.1016/j.actbio.2015.08.015",

language = "English",

volume = "26",

pages = "366--376",

journal = "Acta Biomaterialia",

issn = "1742-7061",

publisher = "Elsevier BV",

}

Santos, PF, Niinomi, M, Cho, K, Nakai, M, Liu, H, Ohtsu, N, Hirano, M, Ikeda, M 2015, 'Microstructures, mechanical properties and cytotoxicity of low cost beta Ti-Mn alloys for biomedical applications', Acta Biomaterialia, vol. 26, pp. 366-376. https://doi.org/10.1016/j.actbio.2015.08.015

Microstructures, mechanical properties and cytotoxicity of low cost beta Ti-Mn alloys for biomedical applications. / Santos, Pedro Fernandes; Niinomi, Mitsuo; Cho, Ken et al.
In: Acta Biomaterialia, Vol. 26, 15.10.2015, p. 366-376.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Microstructures, mechanical properties and cytotoxicity of low cost beta Ti-Mn alloys for biomedical applications

AU - Santos, Pedro Fernandes

AU - Niinomi, Mitsuo

AU - Cho, Ken

AU - Nakai, Masaaki

AU - Liu, Huihong

AU - Ohtsu, Naofumi

AU - Hirano, Mitsuhiro

AU - Ikeda, Masahiko

AU - Narushima, Takayuki

N1 - Publisher Copyright:© 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

PY - 2015/10/15

Y1 - 2015/10/15

N2 - The microstructures, mechanical properties and biocompatibility of low cost β-type Ti-(6-18)Mn alloys were investigated after solution treatment. Ti-9Mn exhibits the best combination of tensile strength and elongation among the fabricated alloys, and its performance is comparable to or superior to those of Ti-6Al-4V ELI (Ti-64 ELI) in terms of every parameter evaluated. A hardness of 338 HV, a Young's modulus of 94 GPa, a 0.2% proof stress of 1023 MPa, an ultimate tensile strength of 1048 MPa and elongation of 19% were obtained for Ti-9Mn. Furthermore, the cell viability and metallic ion release ratios are comparable to those of commercially pure titanium, making this alloy promising for biomedical applications. The Young's modulus is also lower than that of Ti-64 ELI (110 GPa), which can possibly reduce the stress shielding effect in implanted patients. Statement of significance This study evaluates mechanical and biological performance of low cost solution treated β-type Ti-(6, 9, 13 and 18 mass%)Mn alloys. It includes alloys containing a Mn content range higher than most previously published works (which is around or lower than 8 mass%). Furthermore, the effects of the ω phase and the β phase stability of the alloys over some mechanical properties and microstructures are discussed. Ion release behavior under simulated body fluids and cell viability are also evaluated. For the case of the Ti-9Mn, a mechanical and biological performance that is comparable to or superior than that of the widely used Ti-6Al-4V ELI and commercially pure Ti was observed.

AB - The microstructures, mechanical properties and biocompatibility of low cost β-type Ti-(6-18)Mn alloys were investigated after solution treatment. Ti-9Mn exhibits the best combination of tensile strength and elongation among the fabricated alloys, and its performance is comparable to or superior to those of Ti-6Al-4V ELI (Ti-64 ELI) in terms of every parameter evaluated. A hardness of 338 HV, a Young's modulus of 94 GPa, a 0.2% proof stress of 1023 MPa, an ultimate tensile strength of 1048 MPa and elongation of 19% were obtained for Ti-9Mn. Furthermore, the cell viability and metallic ion release ratios are comparable to those of commercially pure titanium, making this alloy promising for biomedical applications. The Young's modulus is also lower than that of Ti-64 ELI (110 GPa), which can possibly reduce the stress shielding effect in implanted patients. Statement of significance This study evaluates mechanical and biological performance of low cost solution treated β-type Ti-(6, 9, 13 and 18 mass%)Mn alloys. It includes alloys containing a Mn content range higher than most previously published works (which is around or lower than 8 mass%). Furthermore, the effects of the ω phase and the β phase stability of the alloys over some mechanical properties and microstructures are discussed. Ion release behavior under simulated body fluids and cell viability are also evaluated. For the case of the Ti-9Mn, a mechanical and biological performance that is comparable to or superior than that of the widely used Ti-6Al-4V ELI and commercially pure Ti was observed.

KW - Biocompatibility

KW - Low cost Ti alloy

KW - Mechanical properties

KW - Ti-Mn alloys

KW - β phase

UR - http://www.scopus.com/inward/record.url?scp=84942294837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942294837&partnerID=8YFLogxK

U2 - 10.1016/j.actbio.2015.08.015

DO - 10.1016/j.actbio.2015.08.015

M3 - Article

C2 - 26283166

AN - SCOPUS:84942294837

SN - 1742-7061

VL - 26

SP - 366

EP - 376

JO - Acta Biomaterialia

JF - Acta Biomaterialia

ER -

Santos PF, Niinomi M, Cho K, Nakai M, Liu H, Ohtsu N et al. Microstructures, mechanical properties and cytotoxicity of low cost beta Ti-Mn alloys for biomedical applications. Acta Biomaterialia. 2015 Oct 15;26:366-376. doi: 10.1016/j.actbio.2015.08.015